Utilize a API SetCursorPos para alterar a posição do cursor na tela. Você define a nova posição em coordenadas(x e y):
Private Declare PtrSafe Function SetCursorPos Lib "user32" (ByVal x As Long, ByVal y As Long) As Long
SetCursorPos 80, 50 'Chamada da função
Para simular um click você pode utilizar a função mouse_event:
Private Declare PtrSafe Sub mouse_event Lib "user32" (ByVal dwFlags As Long, ByVal dx As Long, ByVal dy As Long, ByVal cButtons As Long, ByVal dwExtraInfo As Long)
Private Const MOUSEEVENTF_LEFTDOWN = &H2
Private Const MOUSEEVENTF_LEFTUP = &H4
Private Const MOUSEEVENTF_RIGHTDOWN As Long = &H8
Private Const MOUSEEVENTF_RIGHTUP As Long = &H10
'Clique botão esquerdo
mouse_event MOUSEEVENTF_LEFTDOWN, 0, 0, 0, 0
mouse_event MOUSEEVENTF_LEFTUP, 0, 0, 0, 0
'Duplo clique botão esquerdo
mouse_event MOUSEEVENTF_LEFTDOWN, 0, 0, 0, 0
mouse_event MOUSEEVENTF_LEFTUP, 0, 0, 0, 0
mouse_event MOUSEEVENTF_LEFTDOWN, 0, 0, 0, 0
mouse_event MOUSEEVENTF_LEFTUP, 0, 0, 0, 0
'Clique botão direito
mouse_event MOUSEEVENTF_RIGHTDOWN, 0, 0, 0, 0
mouse_event MOUSEEVENTF_RIGHTUP, 0, 0, 0, 0
