podrias usar la instruccion DELETE
o sea debria ser algo mas especifico en la pregunta, es muy generico lo que planteas
podrias usar
Dim connstring As String = "connection string"
Using cn As New SqlConnection(connstring)
cn.Open()
Dim sql As String = "DELETE Table WHERE id = @param"
Dim cmd As New SqlCommand(query, cn)
cmd.Parameters.AddwithValue("@param1", Textbox1.Text)
cmd.ExecuteNonQuery()
End Using
saludos
Leandro Tuttini
Blog
Buenos Aires
Argentina