.NET Framework Initialization Error Help Cli.exe "Unable to find the runtime to run this application" on startup and when try to open ATI Catalyst Control Center RRS feed

  • Question

  • Hi everybody, I have a machine I am working on that has a problem I want to fix. 

    The problem shows itself upon startup.  As soon as Windows XP finishes loading to the desktop, a window appears showing the error message.  It is titled Cli.exe - .NET Framework Initialization Error."  It states inside the window, "Unable to find the runtime to run this application."  This window also pops up when I try to open the graphics card controlling program ATI Catalyst Control Center. 

    I just formatted one of this machine's hardrives and then installed a fresh install of Windows XP on it.  I installed SP3 over the SP1a  version that came on the Windows XP CD first. Then I think I might have installed the motherboard drivers.  Then I think I updated Windows Update and let it run to get me .NET Framework.  Then I installed the ATI graphics card display driver and ATI Catalyst Control Center.  Specs of computer: AMD Athlon 3000+ Asus A7N8X motherboard, 1.5 GB ram, 80 GB and 60 GB hard drives, 1 CD-RW drive, 1 CD-RW and DVD rom drive, Windows XP Home 32 bit, and ATI 9250 Graphics Card.

    Appreciate any help!

    Wednesday, February 2, 2011 5:40 AM


All replies

  • First, check the integrity of any installed frameworks with this tool:

    You don't mention what .NET Framework version(s) are installed, but remove any that fail the integrity check with this tool:

    Then reinstall the needed framework.

    For Framework v1.1:

    For Framework 2.0/3.0/3.5 (note that 3.0 and 3.5 are extensions of 2.0, not full frameworks):


    • Proposed as answer by martian2001 Tuesday, August 2, 2011 7:01 PM
    • Edited by pvdg42 Wednesday, August 3, 2011 3:30 AM
    Wednesday, February 2, 2011 4:30 PM
  • I decided to run the .Net Framework Cleanup Tool and it successfully deleted all of my .Net Framework files. Next I ran the Windows Update Website Program to help me install .Net Framework. It found .Net Framework 4.0 Client. However, when I tried to install it it failed. The description of the problem was this: "Installation Failure" and "Error Code: 0x643". This has got me thinking that there may be a bigger problem.

    It game me the option to contact a Microsoft professional via E-mail so I have started the process. This was the message I wrote him/her:

    Hi, I just reformatted my computer's harddrives and installed Windows XP Home 32-bit on one of them. The .Net Framework program wasn't being compatible with my ATI Catalyst Center graphics settings controller program. An error would appear titled, "Cli.exe - .Net Inititialization Error" and which said, "Unable to find the version of runtime to run this application." This error window would appear once I was loaded into the desktop of the OS everytime. Also this same window-error appearred when I would try to open up the ATI CCC program. I couldn't get into the program after the message appearred either. To attempt to fix this I downloaded, installed, and ran a .Net Framework Cleanup Tool successfully. Then I tried to use Windows Update to install the 4.0 .Net Framework Client program, but it didn't install successfully. Windows Update gave me this description of the problem: it called it an "Installation Failure" and stated: Error Code: 0x643. I am looking for assistance to how to install this program and/or fix a deeper/more complicated system problem.

    I'll try installing 4.0 .Net Framework after downloading it directly from MS' website.


    I just downloaded 4.0 .Net Framework Client program from MS' website and tried isntalling it. Again, I also got an installation error; it failed to install. It did have an installation log report, but I don't think I would have much success trying to read it myself.
    Wednesday, February 2, 2011 11:59 PM
  • Hi DBean,


    I'm posting to follow up your issue, have your problem been resolved?


    Have you tried the standalone installer to install .NET Framework 4.0?

    Microsoft .NET Framework 4 (Standalone Installer):


    From the I find the caution below:

    The Catalyst® Control Center requires that the Microsoft .NET Framework version 1.1 or 2.0 be installed. Without .NET version 1.1 or 2.0 installed, the Catalyst® Control Center will not launch properly and the user will see an error message.

    For more information, please see:


    Therefore, I suggest you download and install the .NET Framework 3.5 from the link below:


    Before install .NET Framework, please finish the steps below:

    a.       Turn off your anti-virus/antispyware software during installation;

    b.      Install the latest Windows updates from the Windows Update site: ;

    c.       Complete or dismiss Windows Update before installation. (And don't forget to turn it on later);

    d.      Clean your %temp% folder (Start Menu >> Run >> Type "%temp%)


    If the installation still fails, please follow below steps to collect install log files:

    ·         Collect the logs from "%temp%" folder with the Log Collection Tool

    Collect tool:

    ·         Send the file to me (E-mail:

    Note: Please attach the link of this post in the mail.


    Waiting to hear from you.

    Best Regards, 

    Andrew Wu [MSFT]
    MSDN Community Support | Feedback to us
    Get or Request Code Sample from Microsoft
    Please remember to mark the replies as answers if they help and unmark them if they provide no help.

    Monday, February 7, 2011 11:11 AM
  • I had the same problem as the original poster after I reinstalled XP, even after installing Framework4.0.  I used the above removal tool to take off Framework 4, then Installed the 2.0/3.0/3.5 from above link, Success, my ATI catalyst now works.  Thanks for the help, took me hours to find this, too bad this info is not on the Dell Drivers or ATI site.  Thanks again.
    Friday, March 4, 2011 5:04 AM
  • Same thing. I installed Framework 4.0 after I had reinstalled XP, that's when the problem first appeared. Thank you pvdg42 for the help.
    Tuesday, August 2, 2011 7:32 PM