User1508394307 posted
Use OLEDB
http://social.msdn.microsoft.com/Forums/en-US/Vsexpressvcs/thread/9c2d6d93-314c-4ddb-88e8-638c0edfe62b/
and query like Select * FROM [Sheet1$] Where Col1 = 2
or convert all data into a datatable using e.g.
NPOI library and perform further actions.