User-943250815 posted
You can disable button, popup an alert to confirm Save, or even cover page with a transparent div.
Anyway, make sure user gets a Save confirmation, other than no matter waht you do, he/she will continue clicking Save button........
<asp:Button ID="btnSave" runat="server" Text="Save"
UseSubmitBehavior="false"
OnClientClick="this.disabled='true';"
onclick="SaveData_Click"
</asp:button>