These products have compatibility issue with Windows 8 pre-Beta and since these are Security Tools, it is NOT recommended run them in compatibility mode. If you are concern about Anti-Virus, you don't have to be worry, since Windows 8 comes with Windows
Defender that act as Anti-Virus and Anti-Spyware and just make sure it is getting update and is always on. If you want to use Kaspersky and Comodo, you have to wait until, their compatibility issue resolve in future release.
For Windows 8 Anti-Virus , take a look at:
http://cyberdefend.wordpress.com/2011/10/14/anti-virus-for-windows-8-developer-preview/