I think the version of Word is very important if you're talking about using Word's built-in facilities to do the comparison. As you've posted in the VSTO forum - VSTO is a technology that runs
in-process with the Office application - that would be the logical assumption.
If that's not what you want to do, then you are definitely way off-topic in the VSTO forum. And in that case you don't provide anywhere near enough information about what exactly it is you want to do.
I'm guessing that the assistance you require may be found in the forums that discuss the openxml and the older, proprietary file formats. You'll find links to both in the VSTO forum's
Please Read First message.
Cindy Meister, VSTO/Word MVP