I believe your are referencing to the "Storage Spaces Direct" feature of Windows Server 2016 (atleast for No. 2)?
In this case iSCSI-drives are not supported. Take a look at this Page (first point under "Drives", last point under HBA's): https://technet.microsoft.com/en-us/windows-server-docs/storage/storage-spaces/storage-spaces-direct-hardware-requirements
I'm a Microsoft StorSimple black belt and subject matter expert for many years.
If you need any assistantance in projects, pls. feel free to reach out to me.