Sorry, I read your question too quickly.
If all of the apps in question are using the Surface runtime's input stack, you should be fine. Apps that use the Windows input stack (ex. standard Windows apps) will have issues around activation and input focus.
You can verify this by experimenting with two instances of DataVisualizer side-by-side in Simulator. Then try the same thing with something like mspaint.exe.
Btw, in your original question you asked about objects orienting to the users. Note that contact orientation (i.e. rotation) will only be accessible by your app if you're running on an SUR40 or using InputSimulator.exe.
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