Most likely this is happens because Blend trips over some call to WinRT API which is not allowed to be executed under "Blend Design Mode". For example if you try to send a Toast Notification via WinRT API, that would work fine during actual
app runtime (on device or emulator), but would block under Blend. You need to wrap calls to "design-time-unsupported APIs" with if statements checking for whether your app is running under "Blend Design" mode or not.
var isInDesigner = Windows.ApplicationModel.DesignMode.designModeEnabled;
if ( !isInDesigner ){
// here we can call our "non-design-time" APIs
// like sending Toast Notifications..
// as this code only would be executed by app but NOT
// by Blend.
Windows.UI.Notifications.ToastNotificationManager.doSomeCall();
}
I have also answered this question there:
https://social.technet.microsoft.com/Forums/en-US/05944b4b-f073-4169-8716-488446cd57d6/cannot-open-published-siena-app-in-visual-studio-blend