You have to create a database (it could justt be a file) with the list of people to send the news letter. One you have a list of users then you can use the SMTP class to mail the newlettter. See webpage below
http://msdn.microsoft.com/en-us/library/system.net.mail.smtpclient.aspx
If you are sending more than on email you must dispose the class between each email by make the class IDISPOSABLE.
jdweng