Hello Balu,
<<For this, I have changed the registries under 'Classes' from HKCU to HKLM.>>
It seems that you want to deploy this add-in to all users. Here are some threads you could refer to:
Deploying VSTO 2005 SE add-in to Word 2003 for All Users and this article, especially comments of this blog.
For this error, as Ji said in this thread, we need to use caspol to grant full trust to your assembly after installing this add-in. Try to use this command, and now does it works?
Best regards,
Bessie
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