Our server program is a very large C++ program (100s of files, millions of lines). It implements a propritary in-memory database, which can be 10GB and bigger.
Certain of our benchmarks are 5-10% slower when compiled with VS2008, than with VS2005.
This question is probably better asked over on the general C++ forum, this forum is for parallel programming in C++, not general build or compiler issues.
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